Specifically targeting ERK1 or ERK2 kills Melanoma cells

Abstract Background Overcoming the notorious apoptotic resistance of melanoma cells remains a therapeutic challenge given dismal survival of patients with metastatic melanoma.However, recent clinical trials using a BRAF inhibitor revealed encouraging results for patients with advanced BRAF mutant bearing melanoma, but drug resistance accompanied by

read more

Visual representation learning using graph-based higher-order heuristic distillation for cell detection in blood smear images

Background and objective: In many real-world scenarios, including the blood smear domain, it is difficult for detection networks to achieve good performance because image annotation is usually time consuming and expensive.To address this issue, similarity-based distillation (SD) methods, considered the soft version of contrastive learning, are appl

read more